GTX 1080 Ti runs Pathologic 2 at approximately ~68 FPS at 1080p High settings — verdict: SMOOTH. At 1440p: ~47 FPS (PLAYABLE). At 4K: ~25 FPS (STRUGGLE).
The GTX 1080 Ti averages ~68 FPS in Pathologic 2 at 1080P High settings, comfortably above the 60 FPS smooth-play threshold. Frame pacing is stable at this resolution. No GPU upgrade required.
Performance Optimizer
Live SimulationFrequently asked questions — GTX 1080 Ti & Pathologic 2
Can I run Pathologic 2 on GTX 1080 Ti?
Yes. The GTX 1080 Ti delivers approximately 68 FPS in Pathologic 2 at 1080p High settings. This exceeds the 60 FPS smooth-play threshold — gameplay is fluid without any adjustments needed.
What FPS does GTX 1080 Ti get in Pathologic 2 at 1440p?
The GTX 1080 Ti averages approximately 47 FPS in Pathologic 2 at 1440p High settings — verdict: PLAYABLE. Playable at 1440p — consider lowering to Medium for a smoother experience.
Can GTX 1080 Ti run Pathologic 2 at 4K?
The GTX 1080 Ti averages approximately 25 FPS in Pathologic 2 at 4K High settings — verdict: STRUGGLE. 4K is not recommended on this GPU for this title. 1080p or 1440p is the better choice.
About Pathologic 2
Pathologic 2 is a reimagining of the original, focused on the Haruspex, Artemy Burakh. You return to your plague-stricken hometown as a surgeon-healer caught between local kinship traditions, colonial urban power, impossible medicine, hunger, exhaustion, and a clock that never stops. Compared with the 2005 game, it is more mechanically coherent and cinematic, but still intentionally punishing: you…
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